Boron-Catalyzed Silylative Reduction of Nitriles in Accessing Primary Amines and Imines
- 8 July 2015
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 80 (14) , 7281-7287
Abstract
Silylative reduction of nitriles was studied under transition metal-free conditions by using B(C6F5)3 as a catalyst with hydrosilanes as a reductant. Alkyl and (hetero)aryl nitriles were efficiently converted to primary amines or imines under mild conditions. The choice of silanes was found to determine the selectivity: while a full reduction of nitriles was highly facile, the use of sterically bulky silanes allowed for the partial reduction leading to N-silylimines.Keywords
Funding Information
- Institute for Basic Science (IBS-R010-D1)
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