TRIALS OF NEW FORMS OF RADIOTHERAPY FOR LOCALLY ADVANCED BRONCHOGENIC CARCINOMA - IRRADIATION UNDER 95PERCENT O2 PLUS 5PERCENT CO2 INHALATION, UNEVEN FRACTIONATION IRRADIATION AND INTRAOPERATIVE IRRADIATION

Authors:
  • MAM Abe
    M Abe
  • EYE Yabumoto
    E Yabumoto
  • TNT Nishidai
    T Nishidai
  • MTM Takahashi
    M Takahashi
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  • 1 January 1977
    • journal article
    • research article
    • Vol. 153  (3) , 149-158
    • PMID:841605
Abstract
To improve the survival rate of patients with clinically inoperable but localized bronchogenic carcinoma, the following 3 forms of radiotherapy were developed, and the results were analyzed in comparison with those obtained by conventional radiotherapy: irradiation under 95% O2 plus 5% CO2 inhalation, uneven fractionation irradiation, and intraoperative irradiation. The tumor regression rate was most pronounced in the 95% O2 plus CO2 breathing group and the 1 yr survival rate was significantly increased. The long-term survival rate was almost the same as that of patients treated by conventional radiotherapy. In uneven fractionation irradiation, the follow-up period was short, but the preliminary results seem most encouraging. Intraoperative irradiation is indicated for patients with poor pulmonary function, in whom localized malignant lesions were left behind following excision of the main mass. The reason is that a cancerocidal dose can be delivered directly to the unresectable remnants without affecting normal structures.

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