THE PREPARATION OF SOME STEROIDS CONTAINING DEUTERIUM
Authors:
- B. NolinBNB. Nolin
- R. Norman JonesRJR. Norman Jones
- 1 October 1952
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 30 (10) , 727-733
Abstract
The preparation of several deuterated steroids is described, viz.,(i) the trideuteroacetates of the following alcohols: Δ5,7,9-estratrienol-17β;Δ1,5:10 estrienol-3-one-17 (estrone); androstanol-3a; androstanol-3β; an-drostanol-17β; pregnanol-20a; Δ5-pregnenol-3β -one-20; Δ5-pregnenol-3β -one-20-d4-17,21; Δ5-cholestenol-3β; Δ-cholestadienol-3β; ergostanol-3 β; Δ14-ergostenol-3β; Δ22-5-isoergostenol-3a.(ii) Δ 5-pregnenol-3 β -one-20-d3-21 acetate; Δ -pregnenol-3 β -one-20-d4-17,21.(iii) androstanone-3-d4,-2,4; cholestanone-3-d4-2,4; Δ8:14-ergostenone-3-d4-2,4; cholestanone- 7-d2-6; androstanone-17-d2-16.From difficulties encountered in the preparation of cholestanone-7-d2-6, it is inferred that 7-ketones enolize less readily than 3-, 17-, or 20-ketones.Keywords
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