Inhibition of Hormone-Sensitive Adenyl Cyclase by Phenothiazines

Authors:
Publisher website
Google Scholar
Abstract
Chlorpromazine (3 × 10 -4 M ) prevents the stimulation of adenyl cyclase activity in thyroid membranes produced by thyrotropin and prostaglandin, ACTH stimulation of adenyl cyclase in adrenal tissue, and glucagon- and epinephrine-stimulation of adenyl cyclase activity in liver. Baseline activity is unaffected. Parathyroid hormone stimulation of kidney preparations was not inhibited under these conditions. At chlorpromazine concentrations >3 × 10 -4 M F - -stimulated cyclase activity of thyroid and adrenal tissue was increased. Other phenothiazines, trifluoperazine, and prochlorperazine, have similar effects on thyrotropin and F - -stimulated cyclase activity of thyroid. Na + - K + -dependent ATPase of thyroid is also inhibited by chlorpromazine. Since thymol causes a similar dissociation of hormone- and F - -stimulated adenyl cyclase, it is concluded that the surface properties of these agents best account for their effects on adenyl cyclase.

This publication has 15 references indexed in Scilit: