Epidermal growth factor receptor numbers in male and female mouse primary hepatocyte cultures

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Abstract
Epidermal growth factor receptors (EGF‐R) were measured in adult male and female mouse primary hepatocyte cultures. On culture day 1, female hepatocytes had significantly fewer EGF‐R than male hepatocytes (1·3 × 104 versus 6·2 × 105 per cell). Over the next three days, morphological changes consistent with progressive heptocyte dedifferentiation were observed. During this period, EGF‐R numbers progressively increased in female cultures and decreased in male cultures, and by day 4 the sexual difference in EGF‐R numbers was obliterated. These results indicate that a relationship exists between the degree of differentiation in hepatocyte cultures and the expression of EGF‐R on the cell surface.

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