Redox regulation of the MED28 and MED32 mediator subunits is important for development and senescence
- 21 July 2015
- journal article
- research article
- Published by Springer Nature in Protoplasma
- Vol. 253 (3) , 957-963
Abstract
Mediator is a conserved multi-protein complex that acts as a bridge between promoter-bound transcriptional regulators and RNA polymerase II. While redox signaling is important in adjusting plant metabolism and development, the involvement of Mediator in redox homeostasis and regulation only recently started to emerge. Our previous results show that the MED10a, MED28, and MED32 Mediator subunits form various types of covalent oligomers linked by intermolecular disulfide bonds in vitro. To link that with biological significance we have characterized Arabidopsis med32 and med28 mutants and found that they are affected in root development and senescence, phenotypes possibly associated to redox changes.Keywords
This publication has 49 references indexed in Scilit:
- REF4 and RFR1, Subunits of the Transcriptional Coregulatory Complex Mediator, Are Required for Phenylpropanoid Homeostasis in ArabidopsisJournal of Biological Chemistry, 2012
- Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complexNucleic Acids Research, 2008
- Purification of a Plant Mediator from Arabidopsis thaliana Identifies PFT1 as the Med25 SubunitMolecular Cell, 2007
- Evidence for a role of Ethylene-Insensitive 2 gene in the regulation of the oxidative stress response in ArabidopsisActa Physiologiae Plantarum, 2006
- The role of reactive oxygen species in cell growth: lessons from root hairsJournal of Experimental Botany, 2006
- The yeast Mediator complex and its regulationTrends in Biochemical Sciences, 2005
- Antagonistic Interaction between Abscisic Acid and Jasmonate-Ethylene Signaling Pathways Modulates Defense Gene Expression and Disease Resistance in ArabidopsisThe Plant Cell, 2004
- Regulation of flowering time by light qualityNature, 2003
- Cell numbers and leaf development in Arabidopsis: a functional analysis of the STRUWWELPETER geneThe EMBO Journal, 2002
- Evidence for a Mediator of RNA Polymerase II Transcriptional Regulation Conserved from Yeast to ManCell, 2002