QUANTITATIVE EXPERIMENTAL EVALUATION OF ADRIAMYCIN CARDIOTOXICITY IN THE MOUSE

Authors:
  • CBC Bertazzoli
    C Bertazzoli
  • OBO Bellini
    O Bellini
  • UMU Magrini
    U Magrini
  • MTM G Tosana
    M G Tosana
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  • 1 January 1979
    • journal article
    • research article
    • Vol. 63  (11-1) , 1877-1883
    • PMID:526920
Abstract
Adriamycin cardiotoxicity was morphologically evaluated in mice treated i.v. 10 times at 3 dose levels which were equal to fixed fractions of the LD50. Good correlation between the degenerative heart lesions, scored according to a nonparametric scoring system, and the doses was found and allowed calculation of a median cumulative cardiotoxic dose of 36.4 mg/kg of body wt (121.5 mg/m2). The method is suitable for quantitative screening of the potential cardiotoxicity of new anthracycline analogs under standardized conditions.