Desymmetrization of meso‐2,5‐Diallylpyrrolidinyl Ureas through Asymmetric Palladium‐Catalyzed Carboamination: Stereocontrolled Synthesis of Bicyclic Ureas

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Abstract
Lost symmetry: Fused bicyclic ureas are enantioselectively obtained through Pd‐catalyzed desymmetrizing carboaminations of meso‐2,5‐diallylpyrrolidinyl ureas (see scheme). The reactions generate a CN and a CC bond, and afford products with three stereocenters. One of these products was transformed to a tricyclic guanidine and then to 9‐epi‐batzelladine K over several steps.

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