Design, Synthesis, and Validation of a Branched Flexible Linker for Bioactive Peptides
- 6 February 2007
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 72 (5) , 1675-1680
Abstract
A branched flexible linker that incorporates a fluorescent dansyl moiety was synthesized and used to connect two high affinity NDP-α-MSH ligands or two low affinity MSH(4) ligands. The linker was incorporated into the conjugate by solid-phase synthesis. In vitro biological evaluations showed that potency of binding to the human melanocortin 4 receptor was not diminished for linker−ligand combinations relative to the corresponding ligand alone.Keywords
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