Sex differences in cardiovascular disease and dysregulation in Down syndrome

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Abstract
In patients with Down syndrome (DS), CHD is the leading cause of death 20 yr old. Men with DS live longer than women. It is unknown if sex differences are present in cardiovascular disease and dysregulation in DS across the lifespan. We observed higher risk of hypertension, ischemic heart disease, and cerebrovascular disease in females and a higher risk of CHD in males with DS.
Funding Information
  • American Cancer Society (Research Scholar Grant)
  • American Physiological Society (Hearst Fellowship)
  • HHS | NIH | National Center for Advancing Translational Sciences (UL1TR002537)
  • HHS | NIH | National Institute of Child Health and Human Development (R21HD099573)
  • HHS | NIH | National Institute of Child Health and Human Development (3R21HD099573)

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