Acyclic cucurbit[n]uril molecular containers enhance the solubility and bioactivity of poorly soluble pharmaceuticals
Authors:
- Gaya HettiarachchiGHGaya Hettiarachchi
- Duc NguyenDNDuc Nguyen
- Ben ZhangBZBen Zhang
- James B. WittenbergJWJames B. Wittenberg
- Peter Y. ZavalijPeter Y. Zavalij
- Volker BrikenVolker Briken
- Lyle IsaacsLyle Isaacs
- 15 April 2012
- journal article
- Published by Springer Nature in Nature Chemistry
- Vol. 4 (6) , 503-510
Abstract
Acyclic cucurbituril-type molecular containers have been found to increase the solubility of insoluble pharmaceutical agents in water by up to 2,750-fold. In vitro and in vivo toxicology studies suggest that the containers are well tolerated, and paclitaxel solubilized in this manner efficiently kills HeLa and SK-OV-3 cancer cells.Keywords
This publication has 51 references indexed in Scilit:
- Recognition Properties of Acyclic Glycoluril OligomersOrganic Letters, 2011
- Mechanized Silica Nanoparticles: A New Frontier in Theranostic NanomedicineAccounts of Chemical Research, 2011
- Encapsulation of Drug Molecules by Cucurbiturils: Effects on their Chemical Properties in Aqueous SolutionIsrael Journal of Chemistry, 2011
- The Potential of Cucurbit[n]urils in Drug DeliveryIsrael Journal of Chemistry, 2011
- Supramolecular encapsulation of benzimidazole-derived drugs by cucurbit[7]urilCanadian Journal of Chemistry, 2011
- Kinetic resolution of constitutional isomers controlled by selective protection inside a supramolecular nanocapsuleNature Chemistry, 2010
- Toxicology and Drug Delivery by Cucurbit[n]uril Type Molecular ContainersPLOS ONE, 2010
- Self-Organization in Coordination-Driven Self-AssemblyAccounts of Chemical Research, 2009
- Two Mechanisms of Slow Host-Guest Complexation between Cucurbit[6]uril and Cyclohexylmethylamine: pH-Responsive Supramolecular KineticsAngewandte Chemie International Edition, 2001
- Cremophor ELEuropean Journal of Cancer, 2001