Studies of Novel 1, 4-Dihydropyridine Ca Antagonist CS-905. I. Measurement of Partition Coefficient (logP) by High Performance Liquid Chromatography (HPLC)

Authors:
  • ATAkira Takeyasu
    Akira Takeyasu
  • KOKiyoshi Oizumi
    Kiyoshi Oizumi
  • TKTakashi Kobayashi
    Takashi Kobayashi
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Abstract
A new 1,4-dihydropyridine derivative, CS-905, currently under development as a Ca antagonist, showed a gradual onset and long duration in its antihypertensive effect upon single oral administration. The partition coefficient for CS-905 was measured along with 11 known dihydropyridine Ca antagonists by the HPLC method to clarify its mode of action. The log PHPLC for CS-905 was, 5.18, almost the same as that of manidipine and this value is the highest among the measured drugs. Its pharmacokinetic profile in SHR was also discussed.