The Stereochemistry of Organometallic Compounds. XXX. Hydrocyanation of Alkynol Ethers: a New Stereospecific Route to α-Alkylidene γ-Lactones

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Abstract
The regioselectivity of hydrocyanation of a range of protected a- and ß-hydroxyalkynes has been investigated and shown to be highly susceptible to steric effects. Some of the products from hydrocyanation of protected ß-hydroxyalkynes have been converted into a-alkylidene ?- lactones.