Genetic relatedness of Cuban HAV wild-type isolates

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Abstract
Knowledge of the nucleotide sequence in the region of the putative VP1/2A junction of the Hepatitis A virus (HAV) genome has enabled differentiation of HAV strains and their classification into seven genotypes, in some of which sub‐genotypes A and B can be defined. A 168 base segment encompassing the putative VP1/2A junction of 27 clinical wild‐type isolates of HAV from Cuba was amplified by reverse transcriptase‐polymerase chain reaction and then sequenced. The Cuban isolates are clustered within sub‐genotype IA. A single amino acid substitution, which does not correspond with any of the reported changes for other strains, was observed. A new sub‐genotype variant is therefore postulated. This study provides new data on the genetic relatedness of HAVs from Cuba and on the distribution of sub‐genotype IA in the Caribbean area. J. Med. Virol. 64:96–103, 2001.

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