Intestinal mucosal mitochondrial oxidative phosphorylation worsens with cirrhosis progression and is ameliorated with fecal microbiota transplantation

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Abstract
Cirrhosis, the end-stage of liver disease, progresses through altered gut-liver axis and microbial change. Here we show that intestinal mucosal mitochondrial oxidative phosphorylation, which affects intestinal barrier worsens with cirrhosis progression. This is ameliorated with fecal microbiota transplantation.
Funding Information
  • Office of Research and Development (I01CX001076, I01CX002472, I01BX005730, IK6BX004477, 1IS1BX005517-01, 1IS1BX004777-01)
  • National Institute on Alcohol Abuse and Alcoholism (RO1AA0029398)
  • National Institute of Diabetes and Digestive and Kidney Diseases (2R56DK115377-05A1, R01DK139587, R01DK10489)