Functional connectivity in central executive network protects youth against cardiometabolic risks linked with neighborhood violence

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Abstract
Significance: There is considerable variability in how people respond to major stressors. Some remain healthy, whereas others deteriorate. Little is known about the brain networks that are involved in shaping these different outcomes, a problem we pursue here. Like previous studies, we find that youth living in neighborhoods with high levels of violence have worse cardiometabolic health than peers from safer communities. Extending this knowledge, we show this connection is absent for youth who display higher connectivity within the brain’s frontoparietal central executive network (CEN), which facilitates efforts of self-control as well as reinterpretation of threatening events and suppression of unwanted emotional imagery. These observations suggest that CEN connectivity may be a neurobiological contributor to resilience.
Funding Information
  • HHS | NIH | National Heart, Lung, and Blood Institute (HL122328)
  • HHS | NIH | National Institute on Drug Abuse (DA027827)
  • HHS | NIH | National Institute of Mental Health (MH100117)
  • HHS | NIH | National Institute on Deafness and Other Communication Disorders (DC012283)

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