EBC‐219: A New Diterpene Skeleton, Crotinsulidane, from the Australian Rainforest Containing a Bridgehead Double Bond
Authors:
- Elizabeth H. KrenskeElizabeth H. Krenske
- Carly J. PierceCPCarly J. Pierce
- Victoria A. GordonVGVictoria A. Gordon
- Paul W. ReddellPaul W. Reddell
- Peter G. ParsonsPeter G. Parsons
- Craig M. WilliamsCraig M. Williams
- 5 May 2014
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 53 (27) , 7006-7009
Abstract
EBC‐219 (4), isolated from Croton insularis (Baill), was established by spectroscopic and DFT methods as the first member of a new diterpene skeletal class, uniquely defined by the presence of a bicyclo[10.2.1] bridgehead olefin. The proposed biogenetic pathway to 4 from the co‐isolated natural products EBC‐131 (1), EBC‐180 (2) and EBC‐181 (3) is highly likely. EBC‐180 (2) and EBC‐181 (3) showed moderate to strong cytotoxic activity against various cancer cell lines.Keywords
Funding Information
- EcoBiotics Ltd.
- University of Queensland (UQ)
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