A collective strategy to promote the dissemination of single cancer cells
Open Access
- 8 May 2024
- journal article
- editorial
- Published by Rockefeller University Press in Journal of Cell Biology
- Vol. 223 (6)
Abstract
The transition from collective to single-cell invasion in metastatic tumors has been regarded as the consequence of oncogenic drivers in concert with extracellular triggers received from the tumor microenvironment. In this issue, Yoon and colleagues (https://doi.org/10.1083/jcb.202308080) have identified an epigenetic program by which collective niches release laminin-332 and thereby cause the detachment and invasion of fully individualized tumor cells.Keywords
This publication has 10 references indexed in Scilit:
- Subpopulation commensalism promotes Rac1-dependent invasion of single cells via laminin-332Journal of Cell Biology, 2024
- Laminin 332 in cancer: When the extracellular matrix turns signals from cell anchorage to cell movementSeminars in Cancer Biology, 2020
- Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasionNature Communications, 2017
- Plasticity of Cell Migration In Vivo and In SilicoAnnual Review of Cell and Developmental Biology, 2016
- Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) Suppress Cancer Cell Motility via Different MechanismsJournal of Biological Chemistry, 2014
- Processing of Laminin α Chains Generates Peptides Involved in Wound Healing and Host DefenseJournal of Innate Immunity, 2014
- An ESRP‐regulated splicing programme is abrogated during the epithelial–mesenchymal transitionThe EMBO Journal, 2010
- Motility Induction in Breast Carcinoma by Mammary Epithelial Laminin 332 (Laminin 5)Molecular Cancer Research, 2009
- Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1bOncogene, 2000
- Induction of Cell Migration by Matrix Metalloprotease-2 Cleavage of Laminin-5Science, 1997