Studying the effect of Scrophularia striata extract on the improvement of recurrent oral ulcers: A clinical trial study

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Abstract
Background and purpose Recurrent aphthous lesions are one of the most common pathological ulcerative conditions in the oral mucosa. Various studies are seeking to find an appropriate treatment with few complications. This study aimed to investigate the effect of the extract of the medicinal plant Scrophularia striata in reducing pain and improving recurrent oral ulcers. Materials and methods In this clinical trial study, 100 patients with oral ulcers complaints referring to the dental clinic of Ilam University of Medical Sciences were investigated. Patients were randomly assigned to two intervention groups with 10% and 15% hydroalcoholic extract and two control groups with simple diphenhydramine syrup and normal saline serum. The rate of wound healing on days 1 and 3 was assessed by direct examination and observation, and the severity of pain and inflammation on days 1, 2, 3, and 5 was assessed by VAS criteria. Data analysis was performed using SPSS 24 software and statistical tests of mean, standard deviation, Kruskal-Wallis, and Wilcoxon were analyzed at a significance level of 0.05. Results The mean standard deviation of the participants' age was 28.15 ± 29 years, 3% smoked cigarettes, and 59% reported stress. 56% had a wound, and 31% had it on the lower lip. On the first day, the wound size did not differ significantly between the groups (p = 0.266), but on the third day, the mean rank difference in wound size between the groups increased significantly (p < 0.001); There was also no significant difference in the severity of inflammation on the first day (p = 0.042), but from the second day onwards, the differences increased significantly (second day p < 0.001, third day p < 0.001, and fifth day p < 0.001). Conclusion A solution prepared from the Scrophularia striata plant is effective in accelerating the healing process of recurrent oral ulcers and the severity of its inflammation. Given the favorable effects and low complication rate of a solution containing the extract of the Scrophularia striata plant, its use can be recommended to people with recurrent minor oral thrush.
Funding Information
  • Ilam University of Medical Sciences (980002/7)

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