Proinflammatory Cytokine Expression in the Early Phase ofTrypanosoma brucei rhodesienseInfection in Vervet Monkeys (Cercopithecus aethiops)
Open Access
- 1 May 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (5) , 3063-3065
Abstract
A vervet monkey model of trypanosomiasis was used to study inflammatory cytokine responses in serum and cerebrospinal fuid (CSF). Gamma interferon levels were transiently up-regulated in serum between days 6 and 8 of infection, followed by a sustained up-regulation of tumor necrosis factor alpha (TNF-α) and soluble TNF receptor 1. At no time were these cytokines detectable in the CSF.Keywords
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