Identification of scavenger receptor B1 as the airway microfold cell receptor for Mycobacterium tuberculosis

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Mycobacterium tuberculosis (Mtb) can enter the body through multiple routes, including via specialized transcytotic cells called microfold cells (M cell). However, the mechanistic basis for M cell entry remains undefined. Here, we show that M cell transcytosis depends on the Mtb Type VII secretion machine and its major virulence factor EsxA. We identify scavenger receptor B1 (SR-B1) as an EsxA receptor on airway M cells. SR-B1 is required for Mtb binding to and translocation across M cells in mouse and human tissue. Together, our data demonstrate a previously undescribed role for Mtb EsxA in mucosal invasion and identify SR-B1 as the airway M cell receptor for Mtb.
All Related Versions
Funding Information
  • National Institute of Allergy and Infectious Diseases (AI125939)
  • National Institute of Allergy and Infectious Diseases (AI142784)
  • National Institute of Allergy and Infectious Diseases (5T32AI005284)
  • National Heart, Lung, and Blood Institute (HK131597)
  • Burroughs Wellcome Fund (1017894)
  • Welch Foundation (I-1964-20180324)

This publication has 72 references indexed in Scilit: