GOPC facilitates the sorting of syndecan-1 in polarized epithelial cells
Open Access
- 18 August 2022
- journal article
- research article
- Published by American Society for Cell Biology (ASCB) in Molecular Biology of the Cell
- Vol. 33 (10) , ar86
Abstract
The trans-Golgi network coordinates sorting and secretion of proteins and lipids to cellular organelles and the plasma membrane. It is revealed that Sdc1, a heparin sulfated proteoglycan present on basolateral membranes of polarized epithelia, requires the golgin GOPC for basolateral targeting, in contrast to its sorting requirements in nonpolarized cells.Keywords
This publication has 74 references indexed in Scilit:
- Fiji: an open-source platform for biological-image analysisNature Methods, 2012
- Polarized sorting and trafficking in epithelial cellsCell Research, 2012
- Synchronization of secretory protein traffic in populations of cellsNature Methods, 2012
- Molecular functions of syndecan-1 in diseaseMatrix Biology, 2012
- Membrane lipidome of an epithelial cell lineProceedings of the National Academy of Sciences, 2011
- Engineering Peptide Inhibitors To Overcome PDZ Binding PromiscuityAngewandte Chemie International Edition, 2010
- Galectin-9 trafficking regulates apical-basal polarity in Madin–Darby canine kidney epithelial cellsProceedings of the National Academy of Sciences, 2010
- Syntaxin 6 and CAL Mediate the Degradation of the Cystic Fibrosis Transmembrane Conductance RegulatorMolecular Biology of the Cell, 2010
- A PDZ‐Binding Motif Controls Basolateral Targeting of Syndecan‐1 Along the Biosynthetic Pathway in Polarized Epithelial CellsTraffic, 2008
- Solution structure of GOPC PDZ domain and its interaction with the C‐terminal motif of neuroliginProtein Science, 2006