Live Birth and Endometrial Thickness in Unexplained Infertility

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Abstract
Objective: We aimed to demonstrate any possible relationship between endometrial thickness on the day of hCG trigger and live birth rates (LBRs) among women with unexplained infertility who underwent IVF/ICSI-ET cycles. Materials and Methods: We retrospectively collected data from Zeynep Kamil Women's and Children's Disease Training and Research Hospital, IVF Center archive. Cases between 2005 and 2013 were collected. Women aged between 23-39 years with a BMI <30 kg/m2 with fresh embryo transfers were included. Patients were divided into two groups based on their livebirth status (live birth: group 1, no live birth: group 2). Demographic characteristics, treatment regimens, and endometrial thickness on the day of hCG trigger were compared between the two groups. In addition, patients were divided into subgroups according to the endometrial thickness on the day of hCG trigger (≤7 mm, 8 mm, 9 mm, 10 mm, 11 mm, 12 mm, 13 mm, and ≥14 mm, respectively). LBRs were compared between these subgroups. Results: Three hundred fifty-nine cycles (group 1: n=104, group 2: n=255) were included for statistical analysis. Other than estradiol level (pg/mL) on the day of hCG trigger (2517.2±1106.0, 2210.8±991.7, respectively; p=0.011), there were no statistically significant differences between the two groups. Among the subgroups based on endometrial thickness, the highest LBR was detected in the 13 mm subgroup (36.8%) and lowest LBR was detected in 12 mm subgroup (23.9%). However, LBRs were not statistically significant between the subgroups. Conclusion: LBRs do not seem to be affected by endometrial thickness on the day of hCG trigger among couples with unexplained infertility.

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