General and Efficient Copper-Catalyzed Amidation of Saturated C−H Bonds Using N-Halosuccinimides as the Oxidants
Authors:
- 2 July 2008
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 73 (16) , 6207-6212
Abstract
We have developed a general and efficient method for copper-catalyzed amidation of saturated C−H bonds under mild conditions, and the used substrates include benzylic reagents, the N,N-dimethylaniline derivatives, the free carboxamides, and sulfonamides. The protocol uses inexpensive and readily available CuBr/N-halosuccinimide (NBS or NCS) as the catalyst/oxidant, so it provides practical applications for synthesis of various amides via C−H activation.Keywords
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