Differential responses to prostaglandins in the circular and longitudinal muscle layers of the murine ileum

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Abstract
Prostaglandins are lipid mediators that have complex actions on gastrointestinal motility that are highly dependent on the expression of the receptor subtypes where they exert their actions. PGE2 has inhibitory or excitatory effects on circular or longitudinal muscle layers of the small intestine. Despite many studies of the effects of prostaglandins on tissue contractility, little is known about the specific receptors eliciting these effects. The present study examines functional receptor expression in the small intestine.
Funding Information
  • HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (DK057236)

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