Introduction/Objective. The pain that originate of the musculoskeletal structures of the mastication system is one of the symptoms belonging to the category of temporomandibular disorders or temporomandibular dysfunction (TMD). The aim of the research was to evaluate the effect of therapy with stabilizing occlusal splint in the control of painful symptoms of TMD in comparison with the effect of drug therapy. Methods. Using a standard diagnostic protocol Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) proposed by Dworkin and LeResche, a group of 44 patients with painful temporomandibular dysfunctions was included. Patients were divided into three treatment groups by random selection. The first group was treated with stabilization occlusal splint for a period of one month. In the two control groups was carried out a combination therapy with non-steroidal antiinflammatory drug Ibuprofen (Brufen®, Mylan) or Ibuprofen and medicine from benzodiazepine family Diazepam (Diazepam®, Hemofarm) for a period of three weeks. In order to assess the effects of therapy with stabilizing occlusal splint and drug therapy, before and after the therapy, pain intensity measurements were performed with visual analogue scale (VAS) and digital pressure algometer. Results. A significant reduction in the intensity of painful symptoms has been achieved in all three therapeutic groups. No significant differences in the effectiveness of pain reduction between the proposed therapeutic modalities were noted. Conclusion. The obtained results confirm that therapy with stabilization occlusal splint is a valid procedure in the reduction of pain in patients with TMD.