A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy
Top Cited Papers
- 16 May 2016
- journal article
- Published by Springer Nature in Nature Nanotechnology
- Vol. 11 (8) , 724-730
Abstract
A magnetic resonance imaging contrast agent that amplifies its signal in response to pH is used to rapidly identify tumours, report hypoxic regions in the tumour and detect millimetre-sized metastatic tumours in the liver of animals.Keywords
This publication has 46 references indexed in Scilit:
- MRI-detectable pH nanosensors incorporated into hydrogels for in vivo sensing of transplanted-cell viabilityNature Materials, 2013
- M13-templated magnetic nanoparticles for targeted in vivo imaging of prostate cancerNature Nanotechnology, 2012
- A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticleNature Medicine, 2012
- Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on sizeNature Nanotechnology, 2011
- Biocompatible and pH-Sensitive PLGA Encapsulated MnO Nanocrystals for Molecular and Cellular MRIACS Nano, 2011
- Magnetite‐Nanoparticle‐Encapsulated pH‐Responsive Polymeric Micelle as an MRI Probe for Detecting Acidic Pathologic AreasSmall, 2010
- A dual-emissive-materials design concept enables tumour hypoxia imagingNature Materials, 2009
- Determination of Proton Relaxivities of Mn(II), Cu(II) and Cr(III) added to Solutions of Serum ProteinsMolecules, 2009
- Magnetic nanoparticles in MR imaging and drug deliveryAdvanced Drug Delivery Reviews, 2008
- Imaging in the era of molecular oncologyNature, 2008