Pharmacogenomics in Lebanon: current status, challenges and opportunities
- 22 May 2024
- journal article
- review article
- Published by Springer Nature in The Pharmacogenomics Journal
- Vol. 24 (3) , 1-7
Abstract
Pharmacogenomics (PGx) research and applications are of utmost relevance in Lebanon considering its population genetic diversity. Moreover, as a country with regional leadership in medicine and higher education, Lebanon holds a strong potential in contributing to PGx research and clinical implementation. In this manuscript, we first review and evaluate the available PGx research conducted in Lebanon, then describe the current status of PGx practice in Lebanon while reflecting on the local and regional challenges, and highlighting areas for action, and opportunities to move forward. We specifically expand on the status of PGx at the American University of Beirut Faculty of Medicine and Medical Center as a case study and guide for the further development of local and regional comprehensive PGx research, teaching, and clinical implementation programs. We also delve into the status of PGx knowledge and education, and prospects for further advancement such as with online courses and certificates.Keywords
This publication has 77 references indexed in Scilit:
- Cross‐Ancestry Genome‐Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma ConcentrationsClinical Pharmacology & Therapeutics, 2023
- Pharmacogenetics in developing countries and low resource environmentsHuman Genetics, 2021
- Obesity Alters Endoxifen Plasma Levels in Young Breast Cancer Patients: A Pharmacometric Simulation ApproachClinical Pharmacology & Therapeutics, 2020
- SlowN‐acetylation as a possible contributor to bladder carcinogenesisMolecular Carcinogenesis, 2020
- Precision Medicine in Low‐ and Middle‐Income CountriesClinical Pharmacology & Therapeutics, 2019
- NUDT15 and TPMT genetic polymorphisms are related to 6‐mercaptopurine intolerance in children treated for acute lymphoblastic leukemia at the Children's Cancer Center of LebanonPediatric Blood & Cancer, 2016
- CYP2R1 polymorphisms are important modulators of circulating 25-hydroxyvitamin D levels in elderly females with vitamin insufficiency, but not of the response to vitamin D supplementationOsteoporosis International, 2016
- Effects of CYP2B6 genetic polymorphisms in patients receiving cyclophosphamide combination chemotherapy for breast cancerCancer Chemotherapy and Pharmacology, 2014
- Improved accuracy of anticoagulant dose prediction using a pharmacogenetic and artificial neural network-based methodEuropean Journal of Clinical Pharmacology, 2013
- Implementation of an intensive risk‐stratified treatment protocol for children and adolescents with acute lymphoblastic leukemia in LebanonAmerican Journal of Hematology, 2012