Polyethyloxazoline monolayers for polymer supported biomembrane models

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Abstract
The synthesis of polymer monolayers, which are designed to act as “cushions” for lipid membranes attached to solid surfaces, is described. Monolayers of poly(ethyloxazolines) which could act as a polymeric support for biomimetic membranes have been attached to silicon oxide or gold surfaces following different strategies for the surface‐attachment of the polymer chains. The polymers are either bound to the surface through a chemisorption process (“grafting‐to”) or “grown” on the surface of silicon oxide substrates through a cationic ring‐opening polymerization started from the surface of the substrate, creating a surface‐attached polymer monolayer in situ (“grafting from”). The characterization of the surface attached films by various surface analytical techniques and the swelling behavior of the surface‐attached polymer films in moist air are described. The non‐specific adsorption of fibrinogen as a typical example for a strongly adsorbing protein onto the surface attached monolayers is studied.

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