Development and validation of an HPLC-MS/MS method for the determination of filgotinib, a selective Janus kinase 1 inhibitor: Application to a metabolic stability study
- 1 October 2020
- journal article
- research article
- Published by Elsevier in Journal of Chromatography B
- Vol. 1154, 122195
Abstract
No abstract availableKeywords
Funding Information
- King Saud University
This publication has 18 references indexed in Scilit:
- Filgotinib (GLPG0634/GS-6034), an oral selective JAK1 inhibitor, is effective as monotherapy in patients with active rheumatoid arthritis: results from a randomised, dose-finding study (DARWIN 2)Annals of the Rheumatic Diseases, 2017
- Filgotinib (GLPG0634/GS-6034), an oral JAK1 selective inhibitor, is effective in combination with methotrexate (MTX) in patients with active rheumatoid arthritis and insufficient response to MTX: results from a randomised, dose-finding study (DARWIN 1)Annals of the Rheumatic Diseases, 2017
- Clinical remission in patients with moderate-to-severe Crohn's disease treated with filgotinib (the FITZROY study): results from a phase 2, double-blind, randomised, placebo-controlled trialThe Lancet, 2017
- Clinical Confirmation that the Selective JAK1 Inhibitor Filgotinib (GLPG0634) has a Low Liability for Drug-drug InteractionsDrug Metabolism Letters, 2016
- Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Modeling of Filgotinib (GLPG0634), a Selective JAK1 Inhibitor, in Support of Phase IIB Dose SelectionClinical Pharmacokinetics, 2015
- Preclinical Characterization of GLPG0634, a Selective Inhibitor of JAK1, for the Treatment of Inflammatory DiseasesThe Journal of Immunology, 2013
- A rapid, accurate and robust UHPLC–MS/MS method for quantitative determination of BMS-927711, a CGRP receptor antagonist, in plasma in support of non-clinical toxicokinetic studiesJournal of Pharmaceutical and Biomedical Analysis, 2013
- Janus kinase inhibitors in autoimmune diseasesAnnals of the Rheumatic Diseases, 2013
- Validation of high-performance liquid chromatography methods for pharmaceutical analysisJournal of Chromatography A, 2003
- Signaling by Type I and II cytokine receptors: ten years afterCurrent Opinion in Immunology, 2001