Bile induced chronic gastric ulcer in swine

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Abstract
The role of bile in the pathogenesis of chronic gastric ulcer was studied in 10 grown‐up miniature pigs. After an observation period of 14–186 days, 4 pigs out of 5 with total diversion of bile into the stomach developed peptic ulcers in the glandular part of the stomach, whereas none of 5 sham operated pigs developed ulcers after an observation period of 150–196 days. This difference was significant (p<0.05). In all 5 pigs with bile diversion the pyloric gland area enlarged at the cost of the fundic gland area, whereas this was not the case in the 5 controls. This difference was also significant (p<0.01). There was no significant change in gastric emptying after the operations. It is concluded that bile can cause gastric ulcer in the pig.
Funding Information
  • Sundhed og Sygdom, Det Frie Forskningsråd (512-4226)