Monte Carlo Dosimetry Calculation for Boron Neutron-Capture Therapy in the Treatment of Brain Tumors
Authors:
- 1 July 1975
- journal article
- research article
- Published by Taylor & Francis in Nuclear Technology
- Vol. 26 (3) , 320-339
Abstract
The pathology of malignant brain tumors often precludes successful treatment by surgery and standard radiation therapy. Boron neutron-capture therapy consists of the selective loading of tumor with 10B and subsequent irradiation with a thermal or epithermal neutron field. The neutron-capture reaction 10B(n,α)7Li produces high-linear-energy-transfer-charged particles that deposit energy principally within the abnormal tissue that contains a high 10B concentration.Constraints on this therapy modality are imposed by radiation effects in normal tissue from thermal neutrons, neutron-induced gamma rays, fast-neutron and gamma-ray beam contaminants, and also from the 10B(n,α)7Li reactions in circulating blood. The ANDY general geometry Monte Carlo code is used to calculate the space-energy distribution of all pertinent components of the dose within a simple head phantom in an idealized therapy configuration at the Massachusetts Institute of Technology Research Reactor. The effects of 10B concentration, g...Keywords
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