Echinocandins for Candidemia in Adults without Neutropenia
Author:
- 14 September 2006
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 355 (11) , 1154-1159
Abstract
A 62-year-old man has a bloodstream infection with a candida species other than Candida albicans. Caspofungin, an echinocandin antifungal agent, is recommended. The echinocandins are effective in treating candidemia in patients who do not have neutropenia. Their efficacy in the treatment of deep-tissue infections or in the setting of neutropenia has not been established.Keywords
This publication has 26 references indexed in Scilit:
- Invasive candidiasis in the intensive care unitCritical Care Medicine, 2006
- Global trends in candidemia: Review of reports from 1995–2005Current Infectious Disease Reports, 2005
- The Epidemiology and Attributable Outcomes of Candidemia in Adults and Children Hospitalized in the United States: A Propensity AnalysisClinical Infectious Diseases, 2005
- Specific Substitutions in the Echinocandin Target Fks1p Account for Reduced Susceptibility of Rare Laboratory and Clinical Candida sp. IsolatesAntimicrobial Agents and Chemotherapy, 2005
- Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance StudyClinical Infectious Diseases, 2004
- Echinocandin antifungal drugsThe Lancet, 2003
- Global Distribution and Outcomes for Candida Species Causing Invasive Candidiasis: Results from an International Randomized Double-Blind Study of Caspofungin Versus Amphotericin B for the Treatment of Invasive CandidiasisEuropean Journal of Clinical Microbiology & Infectious Diseases, 2003
- In vitro antifungal activity of FK463, a new water-soluble echinocandin-like lipopeptideJournal of Antimicrobial Chemotherapy, 2000
- Susceptibility of fluconazole-resistant clinical isolates of Candida spp. to echinocandin LY303366, itraconazole and amphotericin BJournal of Antimicrobial Chemotherapy, 2000
- Discovery of Novel Antifungal (1,3)-β- d -Glucan Synthase InhibitorsAntimicrobial Agents and Chemotherapy, 2000