Characterization of Antineurofilament Autoantibodies in Creutzfeldt-Jakob Disease

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Abstract
The antineurofilament antibodies found in the serum of a chimpanzee with experimental Creutzfeldt-Jakob disease reacted specifically with the 200,000-dalton polypeptide of the purified neurofilament triplet. They also reacted strongly with thoroughly characterized neurofilament swellings of proximal axons of spinal cord motoneurons from β, β1 iminodipropionitrile (IDPN)-intoxicated rats