Signet Ring Cell Carcinoma of the Stomach Is Significantly Associated with Poor Prognosis and Diffuse Gastric Cancer (Lauren’s): Single-Center Experience of 160 Cases

Authors:
  • USUte Smith
    Ute Smith
  • CJChristina Jäger
    Christina Jäger
  • MSMichael Schäffer
    Michael Schäffer
  • UWUlrich Wellhäußer
    Ulrich Wellhäußer
  • THThomas Hehr
    Thomas Hehr
  • HMHans-Ulrich Markmann
    Hans-Ulrich Markmann
  • ONOliver Nehls
    Oliver Nehls
  • CDClaudio Denzlinger
    Claudio Denzlinger
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Abstract
Aim: The aim of this study was to evaluate survival rates and treatment response in stage I–IV gastric cancer in relation to tumor stage (TNM), histology, Lauren’s classification and tumor localization. Patients and Methods: Clinical and histopathological data of 160 patients with stage I–IV gastric cancer were analyzed in this retrospective, single-center study. Results: Most patients (73.1%) showed an advanced or metastatic tumor stage (III/IV). The median 3-year overall survival (OS) was 20 ± 16.8 months and correlated significantly with tumor stage (I: OS 30.6 ± 15 months vs. IV: 10.4 ± 9.3 months; p < 0.0001). Stage III/IV tumors were significantly more often poorly differentiated (G3; p = 0.011) and located in the corpus region. Signet ring cell (SRC) cancers were found in a larger proportion of these tumors when compared with locally limited gastric cancers (43.1% vs. 16.3%; p = 0.002). SRC tumors occurred predominantly in women and younger patients and histology was significantly more often of the diffuse subtype according to Lauren (7.5% vs. 63.2%; p < 0.0001) and poorly differentiated (G3 in 95% vs. 73%; p = 0.001). Conclusions: SRC gastric cancer correlates with poor histopathological criteria and poor prognosis when compared with other histological subtypes. These observations underline the need for more effective treatment in addition to standard approaches.

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