Derivatization in Mass Spectrometry– 3. Alkylation (Arylation)
- 1 February 2004
- journal article
- review article
- Published by SAGE Publications in European Journal of Mass Spectrometry
- Vol. 10 (1) , 1-19
Abstract
The review is devoted to alkylation (arylation) as a widely employed derivatization procedure for the protection of OH (carboxylic acids, phosphoric acids, sulfonic acids, alcohols, polyols, phenols, enols), SH (thiols) and NH (amines, amides) groups in order to increase volatility, to improve the chromatographic properties and, if possible, mass spectral properties of derivatives. Chemical aspects of derivatization and various alkylation (arylation) reagents and reaction procedures are described. Specific mass spectral (electron ionization, chemical ionization) features of derivatives helpful in identification, structure elucidation, profiling and quantitative determination of the above-mentioned polar compounds by coupled gas chromatography or high-performance liquid chromatography are discussed. Some common analytical applications of the procedures in organic chemistry, clinical chemistry, environmental chemistry etc. are briefly summarized.Keywords
This publication has 105 references indexed in Scilit:
- Determination of phthalic monoesters in aqueous and urine samples by solid‐phase microextraction–diazomethane on‐fibre derivatization–gas chromatography–mass spectrometryJournal of Separation Science, 2003
- Application of analytical derivatizations to the quantitative and qualitative determination of fatty acidsAnalytica Chimica Acta, 2002
- Identification of omega hydroxy fatty acids in biological samples as their pentafluoropropyl derivatives by gas chromatography/mass spectrometry with positive and negative ion detectionRapid Communications in Mass Spectrometry, 2002
- Structural elucidation of dicarboxylated metabolites of nonylphenol polyethoxylate surfactants in surface waters by gas chromatography/tandem mass spectrometryRapid Communications in Mass Spectrometry, 2001
- Structural characteristics of arabinoxylan in barley, malt, and beerFood Chemistry, 2000
- Analysis of Airborne Carboxylic Acids and Phenols as Their Pentafluorobenzyl Derivatives: Gas Chromatography/Ion Trap Mass Spectrometry with a Novel Chemical Ionization Reagent, PFBOHEnvironmental Science & Technology, 1998
- On-line Derivatisation in Combined High-performance Liquid Chromatography–Gas Chromatography–Mass SpectrometryThe Analyst, 1997
- Gas chromatographic determination of carbamate pesticides after flash-heater methylation with trimethylsulfonium hydroxideJournal of Agricultural and Food Chemistry, 1993
- Mass spectral characterization of picolinyl and methyl ester derivatives of isomeric thia fatty acidsJournal of Mass Spectrometry, 1991
- Cyclic polyethers and their complexes with metal saltsJournal of the American Chemical Society, 1967