[The ketogenic diet as an effective treatment for Ohtahara syndrome].

Authors:
Google Scholar
  • 1 January 2011
    • journal article
    • case report
Abstract
We here report on a male infant with Ohtahara syndrome. Tonic spasms in series appeared in an one-month-old baby, with his EEG showing a typical suppression burst pattern. We attempted these therapies in the following order; high-dose pyridoxal phosphate; anti-epileptic drugs; sodium valproate, phenobarbital, clonazepam and clobazam in various doses and combination; ACTH; TRH; and gamma-globulin. These did not, however, prove effective enough. Then we tried the ketogenic diet and brought his seizures under control. Therefore, we recommend that doctors who treat Ohtahara syndrome consider using the ketogenic diet earlier in the treatment regimen if the patient does not seem to be responding to conventional drug therapies.