Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex
- 19 May 2011
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in MedChemComm
- Vol. 2 (7) , 666-668
Abstract
This first in vivo antitumour activity for an organometallic osmium arene complex, [Os(η6-p-cym)(4-(2-pyridylazo)-N,N-dimethylaniline)I]PF6, is reported. The complex delays the growth of HCT116 human colon cancer xenografts in mice, with negligible toxicity. Its activity appears to involve redox mechanisms and its potency towards A2780 ovarian and A549 lung cancer cells is increased significantly in combination with L-buthionine-sulfoximine.Keywords
This publication has 20 references indexed in Scilit:
- Organometallic Osmium Arene Complexes with Potent Cancer Cell CytotoxicityJournal of Medicinal Chemistry, 2010
- In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer modelJournal of Inorganic Biochemistry, 2010
- Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?Nature Reviews Drug Discovery, 2009
- Catalytic organometallic anticancer complexesProceedings of the National Academy of Sciences, 2008
- Highly Antiproliferative Ruthenium(II) and Osmium(II) Arene Complexes with Paullone-Derived LigandsOrganometallics, 2007
- Chloro Half-Sandwich Osmium(II) Complexes: Influence of Chelated N,N-Ligands on Hydrolysis, Guanine Binding, and CytotoxicityInorganic Chemistry, 2007
- Metal-based antitumour drugs in the post genomic eraDalton Transactions, 2006
- Measuring reactive species and oxidative damagein vivoand in cell culture: how should you do it and what do the results mean?British Journal of Pharmacology, 2004
- DNA Interactions of Monofunctional Organometallic Ruthenium(II) Antitumor Complexes in Cell-free MediaBiochemistry, 2003
- Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader11Mention of a trade name, proprietary product, or specific equipment does not constitute a guarantee by the United States Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.Free Radical Biology and Medicine, 1999