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  1. Home
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  3. Supplementary Methods from The Pan-RAF–MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS–MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers
  1. Home
  2. Publications
  3. Supplementary Methods from The Pan-RAF–MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS–MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers

Supplementary Methods from The Pan-RAF–MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS–MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers

Authors:
  • MRMeagan B. Ryan
    Meagan B. Ryan
  • BQBradley Quade
    Bradley Quade
  • NSNatasha Schenk
    Natasha Schenk
  • ZFZhong Fang
    Zhong Fang
  • MZMarshall Zingg
    Marshall Zingg
  • SCSteven E. Cohen
    Steven E. Cohen
  • BSBrooke M. Swalm
    Brooke M. Swalm
  • CLChun Li
    Chun Li
  • AÖAyşegül Özen
    Ayşegül Özen
  • CYChaoyang Ye
    Chaoyang Ye
  • MRMaria Stella Ritorto
    Maria Stella Ritorto
  • XHXin Huang
    Xin Huang

Open Access
Publisher website
Google Scholar
  • 17 June 2026
    • other
    • Published by American Association for Cancer Research (AACR)
    • DOI:10.1158/2159-8290.32697489
Abstract
Supplementary methods with detailed protein production, mass spectrometry, in vivo, and in vitro methodology
Keywords
  • CELL SIGNALING
  • PROTEIN SERINE-THREONINE KINASES
  • DRUG DISCOVERY TECHNOLOGIES
  • STRUCTURAL STUDIES
  • DRUG MECHANISMS
  • CELLULAR RESPONSES TO ANTICANCER DRUGS
  • DRUG TARGETS
  • PROTEIN KINASE & PHOSPHATASE DRUG TARGETS
  • PHARMACOLOGY
  • CELLULAR PHARMACOLOGY
  • PHARMACOKINETICS AND PHARMACODYNAMICS
  • SMALL MOLECULE AGENTS
  • KINASE INHIBITORS
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