Novel and Efficient Synthesis of Pyrimidine Derivatives
- 6 May 2010
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 40 (11) , 1580-1587
Abstract
A new series of 1-alkyl-2-oxo-1,2-dihydro-pyrimidine-5-carboxalic acid amides is described. The reaction of N-((E)-3-(dimethylamino)-2-formylacryloyl) formamidine, an intermediate obtained by Vilsmeier–Haack formylation of acetonitrile with various mono-substituted ureas, provides such compounds in good yields.Keywords
This publication has 8 references indexed in Scilit:
- Synthesis of pyrazolo‐annelated heterocyclic ring compounds such as pyrazolo[3,4‐b]pyridines and pyrazolo[4′,3′:5,6]‐pyrido[2,3‐d]pyrimidinesJournal of Heterocyclic Chemistry, 2007
- A convenient route for the synthesis of pyrazolo[3,4-d]pyrimidine, pyrazolo[3,4-b][1,6]naphthyridine and pyrazolo[3,4-b]quinoline derivativesJournal of Heterocyclic Chemistry, 2006
- Friedländer condensation of 5-aminopyrazole-4-carbaldehydes with reactive α-methylene ketones: Synthesis of pyrazolo[3,4-b]pyridinesJournal of Heterocyclic Chemistry, 2005
- Two ring transformations of 3-methyl-5-nitropyrimidin-4(3H)-one for the construction of azaheterocyclesJournal of the Chemical Society, Perkin Transactions 1, 2000
- Neuere Methoden der präparativen organischen Chemie II. 16. Synthesen mit Säure‐amiden, insbesondere mit FormamidAngewandte Chemie, 1959
- Formamid‐Reaktionen, XI. Darstellung, Eigenschaften und Umsetzungen des PyrimidinsEuropean Journal of Inorganic Chemistry, 1958
- Formamid‐Reaktionen, VIII. Eine Neue Pyrimidin‐SyntheseEuropean Journal of Inorganic Chemistry, 1957
- 102. Some reactions of amidines with derivatives of malonic acidJournal of the Chemical Society (Resumed), 1943