Correlation of Infecting Serovar and Local Inflammation in Genital Chlamydial Infections

Authors:
  • WLWayne Lennington
    Wayne Lennington
  • WVWilbert J. Newhall V
    Wilbert J. Newhall V
  • BKBarry P. Katz
    Barry P. Katz
  • HMHoward T. Morrison
    Howard T. Morrison
  • RJRobert B. Jones
    Robert B. Jones
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Abstract
The relationship between acute inflammation and serovar of Chlamydia trachomatis was evaluated in patients with genital chlamydial infection who attended a sexually transmitted diseases clinic. Polymorphonuclear leukocytes (PMNLS) were enumerated on Gram's-stained smears of endourethral contents in men; cervicitis was scored by visual observation of the endocervix in women. Isolates were serotyped with a monoclonal antibody-based radioimmunoassay. The distribution of serovars in 99 women did not differ in the presence or absence of cervicitis or concurrent gonorrhea. An overall difference (P = .037) was observed when serovar distributions in men with ⩽3 PMNLs (n = 42), ⩾10 PMNLs (n = 41), and gonococcal urethritis (n = 42) were compared. Follow-up pairwise comparisons revealed that men with ⩽3 PMNLs had fewer isolates of serovars F and G than did men with ⩾10 PMNLs (P < .05). No strong overall association was observed between inflammation and serovar.

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