Persistent lymphocytosis of natural killer cells in autoimmune thrombocytopenic purpura (ATP) patients after splenectomy
Authors:
- 1 March 1995
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 89 (3) , 653-655
Abstract
We report three patients with primary autoimmune thrombocytopenic purpura (ATP) who developed an absolute lymphocytosis (lymphocyte count > 5×109/I) after splenectomy and with a lymphocyte count between 5.4 and 8.9×109/I. An immunophenotype study showed that the peripheral blood lymphocytosis was a persistent NK cell expansion (CD2+, CD56+, CD3‐), and was characterized by a typical large granular lymphocytes (LGL) morphology. Two of these three ATP patients were refractory to splenectomy.Keywords
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