Epidemiological analysis of drinking water-type fluorosis areas and the impact of fluorosis on children’s health in the past 40 years in China

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Abstract
This study analyzed the effect of China’s fluorosis prevention and control program, which has been in effect for more than 40 years, and the impact of fluorosis on children’s health. Relevant research studies were retrieved from the following online databases from the time of their inception to May 2022: PubMed, ScienceDirect, Embase, Cochrane, China National Knowledge Infrastructure, and Wanfang. The Review Manager 5.3 software was used in statistical analyses. This article included seventy studies: Thirty-eight studies reported the effect of improving water quality and reducing fluoride content, the incidence rate of dental fluorosis in children, and the level of urinary fluoride, and thirty-two studies reported the intelligence quotient (IQ) and health status of children. Following water improvement strategies, the fluoride levels in drinking water decreased significantly; urinary fluoride levels and dental fluorosis decreased significantly in children. With regard to the effect of fluorosis on the IQ of children, the results showed that the IQ of children in areas with a high fluoride of fluorosis was lesser than that in areas with a low fluoride, and this difference was significant. Based on the prevalence of dental fluorosis and its effect on the intelligence of children, it appears that reducing fluoride levels in drinking water and monitoring water quality are important strategies for the prevention and treatment of fluorosis. Graphical abstract
Funding Information
  • Natural Science Foundation of Guizhou Province (QianKeHe Support [2022]181, QianKeHe Basics -ZK[2023] Key 042)
  • Natural Science Foundation of Guiyang City ([2022]4-3-10, [2022]4-3-2)
  • National Natural Science Foundation of China (82160519, 31660326)
  • Subject Excellent Reserve Talent Project (gyfyxkrc-2023-14)
  • Research project of Education Department of Guizhou Province (QianJiaoJi [2023]037)

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