Action of Streptozotocin on Insulin and Glucagon Responses of Rat Islets

Authors:
  • NKN. Katsilambros
    N. Katsilambros
  • YRY. Rahman
    Y. Rahman
  • MHM. Hinz
    M. Hinz
  • RFR. Fußgänger
    R. Fußgänger
  • KSK. Schröder
    K. Schröder
  • KSK. Straub
    K. Straub
  • EPE. Pfeiffer
    E. Pfeiffer
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Abstract
Experimental diabetes was produced in rats by i.v. streptozotocin injection (65 mg/kg). There was a significant increase in blood glucose and serum glucagon, while there was a significant decrease in serum insulin in diabetic animals as compared with controls. It is of interest that the glucagon elevation in the streptozotocin-induced diabetes in animals is of comparable magnitude to that seen in the ketoacidotic state of human diabetes.