Cord-Blood Transplantation from an Unrelated Donor in an Adult with Chronic Myelogenous Leukemia
Authors:
- Norbert-Claude GorinNGNorbert-Claude Gorin
- Pablo RubinsteinPRPablo Rubinstein
- Sylvie LesageSLSylvie Lesage
- Marie-France PortnoiMPMarie-France Portnoi
- Véronique BarbuVBVéronique Barbu
- Manuel LopezMLManuel Lopez
- Luc DouayLDLuc Douay
- Albert NajmanANAlbert Najman
- 18 July 1996
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 335 (3) , 167-170
Abstract
To circumvent the problems inherent in allogeneic bone marrow transplantation, allogeneic cord blood has been studied as an alternative source of hematopoietic stem cells. Preliminary results with cord blood from an HLA-matched sibling are encouraging, but the experience with this procedure is limited.1-5 Although some 200 transplantations of cord blood have been performed in children,6,7 few have been performed in adults. We describe an adult with chronic myelogenous leukemia who underwent the transplantation of cord-blood stem cells successfully.Keywords
This publication has 23 references indexed in Scilit:
- Probability of progenitor renewal (PPR) and production of clonogenic progeny (CFU‐GM) by primitive adherent progenitor cells in adult human bone marrow and umbilical cord bloodBritish Journal of Haematology, 1995
- Cord Blood Natural Killer Cells Are Functionally and Phenotypically Immature but Readily Respond to Interleukin-2 and Interleukin-12Journal of Interferon & Cytokine Research, 1995
- Transplantation of Cord-Blood Stem Cells into a Patient with Severe ThalassemiaNew England Journal of Medicine, 1995
- Proliferative and Cytotoxic Responses of Human Cord Blood T Lymphocytes Following Allogeneic StimulationCellular Immunology, 1994
- UMBILICAL CORD BLOOD TRANSPLANTATION IN A PATIENT WITH PHILADELPHIA CHROMOSOME-POSITIVE CHRONIC MYELOID LEUKEMIATransplantation, 1993
- Growth of human umbilical-cord blood in longterm haemopoietic culturesThe Lancet, 1992
- HLA-MISMATCHD CORD-BLOOD TRANSPLANATION IN A PATIENT WITH ADVANCED LEUKEMIATransplantation, 1992
- Detection of bcr - abl Fusion in Chronic Myelogeneous Leukemia by in Situ HybridizationScience, 1990
- Hematopoietic Reconstitution in a Patient with Fanconi's Anemia by Means of Umbilical-Cord Blood from an HLA-Identical SiblingNew England Journal of Medicine, 1989
- Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro.Proceedings of the National Academy of Sciences, 1988