Predictive value of the SLC22A18 protein expression in glioblastoma patients receiving temozolomide therapy
Open Access
- 20 March 2013
- journal article
- Published by Springer Nature in Journal of Translational Medicine
- Vol. 11 (1) , 69
Abstract
Our previous study showed that SLC22A18 downregulation and promoter methylation were associated with the development and progression of glioma and the elevated expression of SLC22A18 was found to increase the sensitivity of glioma U251 cells to the anticancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). In this study, we investigated the predictive value of SLC22A18 promoter methylation and protein expression in glioblastoma multiforme (GBM) patients receiving temozolomide (TMZ) therapy.Keywords
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