Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations
Authors:
- 1 August 1983
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 304 (5926) , 507-513
Abstract
Kirsten (Ki)-ras cDNA clones were prepared from human lung and colon carcinoma cell lines expressing an activated c-Ki-ras2 gene. DNA sequence analysis and transfection studies indicate that different point mutations at the same codon can activate the gene; that most human c-Ki-ras2 mRNA uses sequences from a fourth coding exon distinct from that of its viral counterpart; and that at least one cell line is functionally homozygous for the activated gene.Keywords
This publication has 49 references indexed in Scilit:
- Oncogenes in solid human tumoursNature, 1982
- Cellular Transforming GenesScience, 1982
- Oncogenes of Spontaneous and Chemically Induced Tumors1982
- Human-tumor-derived cell lines contain common and different transforming genesCell, 1981
- Activation of related transforming genes in mouse and human mammary carcinomas.Proceedings of the National Academy of Sciences, 1981
- Three different human tumor cell lines contain different oncogenesCell, 1981
- Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblastsNature, 1981
- Transforming activity of human tumor DNAs.Proceedings of the National Academy of Sciences, 1981
- Transforming activity of DNA of chemically transformed and normal cellsNature, 1980
- Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin.Proceedings of the National Academy of Sciences, 1979