Enantioselective Total Synthesis of Spirofungins A and B
- 10 September 2010
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 12 (19) , 4416-4419
Abstract
The enantioselective total synthesis of spirofungins A (1) and B (2) is reported in 14 steps over the longest linear sequence. Key steps include the use of thiazolidinethione-mediated aldol reactions to assemble the major fragments and installation of the C1−C6 side chain using a cross metathesis reaction.Keywords
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