Effect of intra-articular injection of orgotein and saline solution on equine synovia

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Abstract
SUMMARY: Orgotein was injected into the right intercarpal joint of each of 8 horses; the corresponding left joint was left alone (not injected) or was given an injection of normal saline solution. Injection with orgotein caused a transient, marked inflammatory response, evidenced by clinical signs and by increased leukocytes and total protein in the synovia (synovial fluid). Leukocyte numbers and total protein concentration were increased (P < 0.010) in the orgotein-injected joints within 24 hours. However, saline solution alone also elicited a marked inflammatory response, manifested by increased leukocyte count and total protein concentration. By 7 days, leukocyte and total protein values had returned to approximately base line in all joints.

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