Biomimetic Enantioselective Total Synthesis of (−)-Petromindole
- 16 January 2018
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 20 (3) , 632-635
Abstract
The first enantioselective total synthesis of (−)-petromindole, an architecturally distinct congener of indole diterpene family, has been achieved. Key features of this synthetic route include the scalable and concise synthesis of tricyclic allylic alcohol from enantiopure Wieland–Mischer ketone derivative, and TMSOTf-mediated, highly efficient biomimetic C-4 cyclization of indole derivative for the rapid construction of a hexacyclic skeleton of petromindole.Keywords
Funding Information
- Council of Scientific and Industrial Research
- Indian Institute of Technology Kanpur
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